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PSGL-1 Antibody / CD162

CAT: 0800-V4317-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V4317-100UGSize:100 µg
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Description
CD162 glycoprotein functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response.
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
Q14242
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant full-length human protein was used as the immunogen for the PSGL-1 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
PSGL1/8192R
Type
Recombinant
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the PSGL-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This PSGL-1 antibody is available for research use only.
Storage Conditions
Aliquot the PSGL-1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the PSGL-1 antibody should be determined by the researcher.
Location
Cell surface
Image Legend
IHC staining of FFPE human spleen tissue with PSGL-1 antibody (clone PSGL1/8192R) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · Q14242

P-selectin glycoprotein ligand 1

SELPL_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q14242
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SELPLG
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PSGL-1
EC number
—
Processing
Precursor
Secondary accessions
A8K2Y0, B4DQC3, B7Z5C7, J3KMX6, Q12775, Q6GTW7, Q8N7J7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesionHost-virus interaction

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoproteinPhosphoproteinPyrrolidone carboxylic acidSulfation

Molecular function

Host cell receptor for virus entryReceptor

Cellular component

Membrane

Domain

RepeatSignalTransmembraneTransmembrane helix

Ligand

Sialic acid

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