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IL-18 Antibody

CAT: 0800-V4198-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V4198-100UGSize:100 µg
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Description
Four structurally related IL-1 receptor ligands have been described. These include three agonists designated IL-1Alpha, IL-1beta and IL-1gamma/IL-18 and a specific receptor antagonist, IL-1RAlpha. IL-1Alpha and IL-1beta play critical roles in the regulation of the immune response and inflammation, serving as activators of T and B lymphocytes and NK (natural killer) cells. IL-18 (also referred to as IL-1gamma) has been shown to augment the secretion of IFN-gamma from T lymphocytes and increase NK cell activity in spleen cells. IL-18 exhibits 19% and 12% identity with IL-1Alpha and IL-1beta respectively over the 12 beta-strands of the beta-trefoil fold domain, which is a signature feature of the IL-1 family. The unusual leader sequence of IL-18 may be analogous to the IL-1beta pro-domain which must be cleaved by the serine protease ICE for optimal secretion and biological activity. Originally described as IGIF (IFN-gamma-inducing factor), IL-18 is induced by mouse liver subsequent to challenge with lipopolysaccharide (LPS) .
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
Q14116
Host
Mouse
Reactivity
Human
Immunogen
A recombinant partial protein (within amino acids 1-193) from the human protein was used as the immunogen for the IL-18 antibody.
Clonality
Monoclonal
Isotype
IgG2 κ
Clone
IL18/4624
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the IL-18 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This IL-18 antibody is available for research use only.
Storage Conditions
Aliquot the IL-18 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the IL-18 antibody should be determined by the researcher.
Location
Secreted
Image Legend
IHC staining of FFPE human kidney tissue with IL-18 antibody (clone IL18/4624) at 2ug/ml. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · Q14116

Interleukin-18

IL18_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q14116
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IL18
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IL-18
EC number
—
Processing
Precursor
Secondary accessions
O75599, Q6FGY3, Q6WWJ7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Molecular function

Cytokine

Cellular component

CytoplasmSecreted

Biological process

Inflammatory response

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