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C-RET Antibody

CAT: 0800-V4093-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V4093-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The Ret proto-oncogene is structurally related to the growing family of tyrosine kinase transmembrane receptors and is involved in GDNF signaling. RET expression is reported in several regions of the central nervous system; in the developing cranial nerve ganglia and a subset of cells within dorsal root ganglia, in motor neurons in the spinal cord and hindbrain, in neuro-retina and the growing tips of the renal collecting ducts in developing kidney. Alterations in RET gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma, and a congenital developmental disorder known as Hirschsprung s disease.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P07949
Host
Mouse
Reactivity
Human
Immunogen
A recombinant partial protein (within amino acids 702-848) from the human protein was used as the immunogen for the c-RET antibody.
Clonality
Monoclonal
Isotype
IgG2c κ
Clone
RET/8791
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the c-RET antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This c-RET antibody is available for research use only.
Storage Conditions
Aliquot the c-RET antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the c-RET antibody should be determined by the researcher.
Location
Membrane
Image Legend
IHC staining of FFPE human parathyroid tissue with c-RET antibody (clone RET/8791) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P07949

Proto-oncogene tyrosine-protein kinase receptor Ret

RET_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P07949
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
RET
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
A8K6Z2, Q15250, Q9BTB0, Q9H4A2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Ligand

ATP-bindingNucleotide-binding

Biological process

Cell adhesion

Cellular component

Cell membraneEndosomeMembrane

Disease

Disease variantHirschsprung diseaseProto-oncogene

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

KinaseReceptorTransferaseTyrosine-protein kinase

Domain

SignalTransmembraneTransmembrane helix

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