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CXCR7 Antibody

CAT: 0800-RQ7428Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ7428Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Atypical chemokine receptor 3 also known as C-X-C chemokine receptor type 7 (CXCR-7) and G-protein coupled receptor 159 (GPR159) is a protein that in humans is encoded by the ACKR3 gene. This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV) . Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL, Flow cytometry: 1-3ug/million cells
UniProt
P25106
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids RNYRYELMKAFIFKYSAKTGLTKLIDASRVSE from the human protein were used as the immunogen for the CXCR7 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, FACS
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the CXCR7 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This CXCR7 antibody is available for research use only.
Storage Conditions
After reconstitution, the CXCR7 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the CXCR7 antibody should be determined by the researcher.
Location
Cell membrane, cytoplasm
Image Legend
IHC staining of FFPE human urothelial carcinoma tissue with CXCR7 antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.

UniProtKB · P25106

Atypical chemokine receptor 3

ACKR3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P25106
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ACKR3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K6J4, Q53RV4, Q8NE10, Q92938, Q92986
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Cell adhesionHost-virus interaction

Cellular component

Cell membraneEndosomeMembrane

Molecular function

Developmental proteinG protein-coupled receptorReceptorTransducer

Disease

Disease variant

PTM

Disulfide bondGlycoproteinPhosphoproteinUbl conjugation

Domain

TransmembraneTransmembrane helix
Product Datasheet
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