Taraxasterol

• Description :

  Taraxasterol is a pentacyclic triterpenoid compound isolated from Taraxacum mongolicum. Taraxasterol is an LXRα activator, with metabolic and anti-inflammatory effects. Taraxasterol may be used in research on immune-inflammatory diseases[1][2][3].

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Interleukin Related; LXR

• Type :

  Natural Products

• Related Pathways :

  Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/taraxasterol.html

• Purity :

  99.41

• Solubility :

  DMSO : 1 mg/mL (ultrasonic; heat to 80°C) |Ethanol : 4 mg/mL (ultrasonic)

• Smiles :

  CC(C)([C@]1([H])CC[C@@]([C@](CC[C@@](CC2)3C)4C)5C)[C@@H](O)CC[C@]1(C)[C@@]5([H])CC[C@]4([H])[C@@]3([H])[C@H](C)C2=C

• Molecular Formula :

  C30H50O

• Molecular Weight :

  426.72

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Zhang X, et al. Effects of taraxasterol on inflammatory responses in lipopolysaccharide-induced RAW 264.7 macrophages. J Ethnopharmacol. 2012 May 7;141 (1) :206-11.|[2]Sang R, Yu Y, Ge B, Xu L, Wang Z, Zhang X. Taraxasterol from Taraxacum prevents concanavalin A-induced acute hepatic injury in mice via modulating TLRs/NF-κB and Bax/Bc1-2 signalling pathways. Artif Cells Nanomed Biotechnol. 2019;47 (1) :3929-3937. |[3]Zheng F, et al. Anti-inflammatory effects of taraxasterol on LPS-stimulated human umbilical vein endothelial cells[J]. Inflammation, 2018, 41: 1755-1761.|[4]San Z, et al. Protective effect of taraxasterol on acute lung injury induced by lipopolysaccharide in mice[J]. International Immunopharmacology, 2014, 19 (2) : 342-350.|[5]Piao T, et al.Taraxasterol inhibits IL-1β-induced inflammatory response in human osteoarthritic chondrocytes. Eur J Pharmacol. 2015 Jun 5;756:38-42.|[6]Movahhed M, et al. Anti-metastatic effect of taraxasterol on prostate cancer cell lines. Res Pharm Sci. 2023 Jun 1;18 (4) :439-448.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [1059-14-9]