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Sibiromycin

CAT: 0804-HY-N9460-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N9460-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sibiromycin is a naturally produced glycosylated pyrrolobenzodiazepines (PBDs) . Sibiromycin is also a potent antitumor antibiotic that binds covalently to DNA in the minor groove at the NH2 of guanine[1][2].
CAS Number
12684-33-2
UNSPSC
12352005
Target
Antibiotic; DNA Alkylator/Crosslinker
Type
Natural Products
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sibiromycin.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=CC(O[C@H]3[C@@H]([C@](O)([C@H]([C@@H](O3)C)NC)C)O)=C(C)C(O)=C2N[C@@H]([C@@]4([H])N1C=C(C4)/C=C/C)O
Molecular Formula
C24H33N3O7
Molecular Weight
475.53
References & Citations
[1]Gerratana B. Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines. Med Res Rev. 2012;32 (2) :254-293.|[2]Li W, et al. Biosynthesis of sibiromycin, a potent antitumor antibiotic. Appl Environ Microbiol. 2009;75 (9) :2869-2878.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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