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Syntelin

CAT: 0804-HY-121569-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-121569-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Syntelin is a selective centromere protein E (CENP-E) inhibitor with IC50 at 160 nM. Syntelin has antitumor activity[1][2].
CAS Number
438481-33-5
UNSPSC
12352005
Target
Kinesin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/syntelin.html
Purity
98.25
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(CSC1=NN=C(N1C2=CC=CC=C2)CSC3=NC(N)=C4C5=C(SC4=N3)CCCC5)O
Molecular Formula
C21H20N6O2S3
Molecular Weight
484.62
References & Citations
[1]Xue biao Yao, et al. Small molecule inhibitor syntelin against kinetochore motor protein cenp-e and use thereof. WO2012062044A1. 2012-05-18.|[2]Mullen M, et al. Syntelin inhibits triple-negative breast cancer cell proliferation and metastasis. J Mol Cell Biol. 2022 Jan 21;13 (11) :834-837.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Kinesin-7/CENP-E

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