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Ethylmalonic acid

CAT: 0804-HY-34740-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-34740-01Size:500 mg
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Description
Ethylmalonic acid is a short-chain organic dicarboxylic acid. Ethylmalonic acid synergistically induces mitochondrial permeability transition (MP) with Ca2+, inhibits Mi-CK, and disrupts mitochondrial energy metabolism. Ethylmalonic acid can be used in the research of SCADD, EE and other genetic metabolic diseases characterized by EMA accumulation[1][2][3][4].
CAS Number
601-75-2
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
Mitochondrial Metabolism
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Propanedioic_acid,_2-ethyl-.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(O)C(CC)C(O)=O
Molecular Formula
C5H8O4
Molecular Weight
132.11
Precautions
H315, H319, H335
References & Citations
[1]Cecatto C, et al. Ethylmalonic acid induces permeability transition in isolated brain mitochondria. Neurotox Res. 2014 Aug;26 (2) :168-78.|[2]Leipnitz G, et al. Ethylmalonic acid inhibits mitochondrial creatine kinase activity from cerebral cortex of young rats in vitro. Neurochem Res. 2003 May;28 (5) :771-7.|[3]Schuck PF, et al. Promotion of lipid and protein oxidative damage in rat brain by ethylmalonic acid. Neurochem Res. 2010 Feb;35 (2) :298-305.|[4]Schuck PF, et al. Brain and muscle redox imbalance elicited by acute ethylmalonic acid administration. PLoS One. 2015 May 26;10 (5) :e0126606.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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