Products for Research Use Only
RegisterLogin

HER-4 Antibody / ERBB4

CAT: 0013-GTR18082620-01Size: 20 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR18082620-01Size:20 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full-length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum. Its expression in breast cancer, pediatric brain cancer and other types of carcinomas has been reported in studies which suggest ErbB4 expression is involved in both normal tissue development and carcinogenesis.
UniProt
Q15303
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 1116-1269) was used as the immunogen for the HER-4 antibody.
Clonality
Monoclonal
Clone
HFR-1
Conjugation
Unconjugated
Field of Research
Cell Biology
Purification
Protein G affinity chromatography
Dilution
Flow cytometry: 1-2ug/10^6 cells in 0.1ml, Immunofluorescence: 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the HER-4 antibody should be determined by the researcher.
Tested Applications
FACS, IF
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
Isotype
Mouse IgG2b, kappa

UniProtKB · Q15303

Receptor tyrosine-protein kinase erbB-4

ERBB4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q15303
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ERBB4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
B7ZLD7, B7ZLE2, B7ZLE3, Q2M1W1, Q59EW4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDevelopmental proteinKinaseReceptorTransferaseTyrosine-protein kinase

Coding sequence diversity

Alternative splicing

Disease

Amyotrophic lateral sclerosisDisease variantNeurodegeneration

Biological process

ApoptosisLactationTranscriptionTranscription regulation

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneMembraneMitochondrionNucleus

PTM

Disulfide bondGlycoproteinPhosphoproteinUbl conjugation

Domain

RepeatSignalTransmembraneTransmembrane helix

Related Products

CatalogName
GTR17691065ErbB 4/ERBB4 Rabbit Polyclonal Antibody
GTR17690301ErbB 4/ERBB4 Rabbit Polyclonal Antibody
GTR18074583-01HER4 / ErbB4 Antibody
GTR18222559ERBB4/HER4 Antibody
GTR18222684ERBB4/HER4 Antibody
GTR18222683ERBB4/HER4 Antibody
GTR18222557ERBB4/HER4 Antibody
GTR18559653ErbB 4/ERBB4 Rabbit Polyclonal Antibody (HRP)
GTR18729739ErbB 4/ERBB4 Rabbit Polyclonal Antibody (Fluoro550)
GTR18729738ErbB 4/ERBB4 Rabbit Polyclonal Antibody (Fluoro594)

Alternative Products

CatalogName
V7741-20UGHER-4 Antibody / ERBB4
36-2237-20Anti-HER-4 / ERBB4 Monoclonal Antibody (Clone: ERBB4/2581)
36-2238-20Anti-HER-4 / ERBB4 Monoclonal Antibody (Clone: HFR-1)
TA354362ErbB 4 (ERBB4) Mouse Monoclonal Antibody
TA422202ErbB 4 (ERBB4) Rabbit Monoclonal Antibody
TA375960ErbB 4 (ERBB4) Rabbit Polyclonal Antibody
PA1881Anti-ErbB 4/ERBB4 Antibody Picoband®
AP12623PU-NErbB 4 (ERBB4) pTyr1188 Rabbit Polyclonal Antibody
PAV7033Rabbit Anti-ERBB-4/ERBB4 Polyclonal Antibody
PA1881-Fluoro647Anti-ErbB 4/ERBB4 Antibody Picoband® Fluoro647 Conjugated

Popular Products