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L-DOPA-2,5,6-d3

CAT: 0804-HY-132392S-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-132392S-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L-DOPA-2,5,6-d3 is the deuterium labeled L-DOPA. L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain[1][2][3].
CAS Number
53587-29-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Dopamine Receptor; Endogenous Metabolite
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
98.80
Solubility
H2O : 25 mg/mL (ultrasonic; warming; adjust pH to 1 with HCl; heat to 60°C)
Smiles
C([C@@H](C(O)=O)N)C1=C(C(O)=C(O)C(=C1[2H])[2H])[2H]
Molecular Formula
C9H8D3NO4
Molecular Weight
200.21
Precautions
H302, H315, H319, H335
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Hyland K, et al. Aromatic L-amino acid decarboxylase deficiency: diagnostic methodology. Clin Chem. 1992 Dec;38 (12) :2405-10.|[3]Merims D, et al. Dopamine dysregulation syndrome, addiction and behavioral changes in Parkinson's disease. Parkinsonism Relat Disord. 2008;14 (4) :273-80. Epub 2007 Nov 7.|[4]Perez-Pardo P, et al. Additive Effects of Levodopa and a Neurorestorative Diet in a Mouse Model of Parkinson's Disease. Front Aging Neurosci. 2018 Aug 3;10:237.|[5]Park HJ, et al. Anti-allodynic effects of levodopa in neuropathic rats. Yonsei Med J. 2013 Mar 1;54 (2) :330-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
D3 Receptor

Chemical Information

3-Hydroxy-L-(2,5,6-~2~H_3_)tyrosine
CAS Number53587-29-4
PubChem CID6914094
IUPAC Name(2S)-2-amino-3-(2,3,6-trideuterio-4,5-dihydroxyphenyl)propanoic acid
Molecular FormulaC9H11NO4
Molecular Weight200.21
XLogP-2.7
Topological Polar Surface Area104
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count14
Formal Charge0
Complexity209
SMILES
[2H]C1=C(C(=C(C(=C1C[C@@H](C(=O)O)N)[2H])O)O)[2H]
InChI
InChI=1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1/i1D,2D,4D
InChIKey
WTDRDQBEARUVNC-UOCCHMHCSA-N
Chemical Structure
2D Structure
2D structure of 3-Hydroxy-L-(2,5,6-~2~H_3_)tyrosine
CAS: 53587-29-4
CID: 6914094
Formula: C9H11NO4
MW: 200.21
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight200.21
XLogP3-2.7
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass200.08763807
Monoisotopic Mass200.08763807
Topological Polar Surface Area104 Ų
Heavy Atom Count14
Formal Charge0
Complexity209
Isotope Atom Count3
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
TMIJ-0312-01L-DOPA-2,5,6-d3
D533762L-Dopa-2,5,6,α,β,β-d6
TRC-M303827-25MGN-Methyl-L-DOPA-d3
MBS6114997-01L-DOPA-2,5,6-d3 (Levodopd3, L-3-Hydroxytyrosine-d3, 3-Hydroxy-L-tyrosine-d3, (-)-3-(3,4-Dihydroxyphenyl-2,5,6-d3)-L-alanine, Bendopa-d3, Deadopa-d3, Dopaflex-d3, Dopal-d3, Dopaidan-d3, Dopalina-d3, Dopar-d3)
D8999-02L-DOPA-2,5,6-d3 (Levodopd3, L-3-Hydroxytyrosine-d3, 3-Hydroxy-L-tyrosine-d3, (-) -3- (3,4-Dihydroxyphenyl-2,5,6-d3) -L-alanine, Bendopa-d3, Deadopa-d3, Dopaflex-d3, Dopal-d3, Dopaidan-d3, Dopalina-d3, Dopar-d3)
CS-C-01365L-Dopa-2,5,6, a, b, b-d6
BA9933-56-Hydroxy-L-DOPA
TRC-D491545-500MG4,5-Dimethoxy-6-Fluoro L-DOPA
0167583-O-Methyl-L-DOPA-d3 Monohydrate
TRC-H590902-2.5MGL-Homocitrulline-2,6,6-d3

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