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Sunitinib-d10

CAT: 0804-HY-10255AS-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10255AS-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sunitinib-d10 (SU 11248-d10) is a deuterium labeled Sunitinib. Sunitinib is a multi-targeted receptor tyrosine kinase inhibitor with IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively[1]. Sunitinib, an ATP-competitive inhibitor, effectively inhibits autophosphorylation of Ire1α by inhibiting autophosphorylation and consequent RNase activation[2].
CAS Number
1126721-82-1
Product Name Alternative
SU 11248-d10
UNSPSC
12352005
Hazard Statement
H360-H372
Target
Apoptosis; Autophagy; IRE1; Mitophagy; PDGFR; VEGFR
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.89
Solubility
10 mM in DMSO|DMSO : 20.83mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C(C1=C(C)NC(/C=C2C(NC3=C\2C=C(F)C=C3)=O)=C1C)NCCN(C([2H])([2H])C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])[2H]
Molecular Formula
C22H17D10FN4O2
Molecular Weight
408.54
Precautions
P260-P264-P270-P280-P405-P501
References & Citations
[1]Sun L, et al. Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol- (3Z) -ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl) amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase. J Med Chem. 2003 Mar 27;46 (7) :1116-9.|[2]Ali MM, et al. Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response. EMBO J. 2011 Mar 2;30 (5) :894-905.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
PDGFRβ; VEGFR2/KDR/Flk-1

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