ALK5-IN-8

ALK5-IN-8

• CAS Number: 2705900-81-6
• UNSPSC Description: ALK5-IN-8 is a potent inhibitor of TGFβRI (ALK5). ALK5-IN-8 Inhibits the phosphorylation of ALK5 on its downstream signaling proteins (Smad2 or Smad3) by blocking the binding of TGFβRI to ligands, thereby affecting or blocking TGF-β signaling. ALK5-IN-8 has the potential for the research of various ALK5-mediated related diseases (extracted from patent WO2021190425A1, compound 1)[1].
• Target Antigen: TGF-β Receptor
• Type: Reference compound
• Related Pathways: TGF-beta/Smad
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/alk5-in-8.html
• Solubility: DMSO : 50 mg/mL (ultrasonic)
• Smiles: O=C(C1=C2C=C(C3=CNN=C3C4=CC=C(F)C=C4)C=CN2N=C1)OCC
• Molecular Weight: 350.35
• References & Citations: [1] Zhiyong Yu, et al. Transforming growth factor-beta receptor inhibitor. Patent WO2021190425A1.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported