Products for Research Use Only
RegisterLogin

LY83583

CAT: 0804-HY-W013386-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-W013386-02Size:10 mM - 1 mL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
LY83583 is inhibitor of soluble guanylate cyclase (sGC) with the ability to target the cGMP signaling pathway. LY83583 inhibits the kinase activity-related proliferation of tumor cells by inducing the Cdk inhibitor p21. LY83583 can be used for the study of cancers (colorectal cancer, breast cancer and melanoma) and cardiovascular disease[1][2][3][4].
CAS Number
91300-60-6
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Guanylate Cyclase
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ly83583.html
Concentration
10mM
Purity
99.84
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C1C=C(NC2=CC=CC=C2)C(C3=C1N=CC=C3)=O
Molecular Formula
C15H10N2O2
Molecular Weight
250.26
Precautions
H315, H319, H335
References & Citations
[1]Lodygin D, et al. Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner. J Clin Invest. 2002 Dec;110 (11) :1717-27. |[2]Kontos HA, et al. Hydroxyl radical-dependent inactivation of guanylate cyclase in cerebral arterioles by methylene blue and by LY83583. Stroke. 1993 Mar;24 (3) :427-34.|[3]Prasad RK, et al. LY-83583 stimulates glucose transporter-1-mediated glucose transport independent of changes in cGMP levels. Eur J Pharmacol. 1999 Jan 29;366 (1) :101-9.|[4]Ribeiro AC, et al. The effects of intracerebroventricular application of 8-Br-cGMP and LY-83,583, a guanylyl cyclase inhibitor, on sleep-wake activity in rats. Brain Res. 2005 Jul 5;1049 (1) :25-33.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

6-(Phenylamino)-5,8-quinolinedione

6-anilino-5,8-quinolinedione is a quinolone that is quinoline-5,8-dione in which the hydrogen at position 6 is replaced by an anilino group. It has a role as an antineoplastic agent and an EC 4.6.1.2 (guanylate cyclase) inhibitor. It is a quinolone, a member of p-quinones, an aromatic amine and an aminoquinoline.

CAS Number91300-60-6
PubChem CID3976
IUPAC Name6-anilinoquinoline-5,8-dione
Molecular FormulaC15H10N2O2
Molecular Weight250.25
XLogP2.5
Topological Polar Surface Area59.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count19
Formal Charge0
Complexity410
SMILES
C1=CC=C(C=C1)NC2=CC(=O)C3=C(C2=O)C=CC=N3
InChI
InChI=1S/C15H10N2O2/c18-13-9-12(17-10-5-2-1-3-6-10)15(19)11-7-4-8-16-14(11)13/h1-9,17H
InChIKey
GXIJYWUWLNHKNW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 6-(Phenylamino)-5,8-quinolinedione
CAS: 91300-60-6
CID: 3976
Formula: C15H10N2O2
MW: 250.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight250.25
XLogP32.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass250.074227566
Monoisotopic Mass250.074227566
Topological Polar Surface Area59.1 Ų
Heavy Atom Count19
Formal Charge0
Complexity410
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
406381LY83583
217526LY 83583 (LY83583, 6-Anilino-5,8-quinolinequinone)

Popular Products