m-PEG12-amine

• UNSPSC Description:

  m-PEG12-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG12-amine is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

• Target Antigen:

  ADC Linker; PROTAC Linkers

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/m-peg12-amine.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN

• Molecular Weight:

  559.69

• References & Citations:

  [1]Vasco AV, et al. A Multicomponent Stapling Approach to Exocyclic Functionalized Helical Peptides: Adding Lipids, Sugars, PEGs, Labels, and Handles to the Lactam Bridge. Bioconjug Chem. 2019 Jan 16;30(1):253-259.|[2] Joseph Fox, et al. Methods for inducing bioorthogonal reactivity. WO2017106427A1.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported

• CAS Number:

  1977493-48-3