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Silodosin (Standard)

CAT: 0804-HY-10122R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10122R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Silodosin (Standard) is the analytical standard of Silodosin. This product is intended for research and analytical applications. Silodosin (KAD 3213; KMD 3213) is a potent, selective and orally active α1A-adrenergic receptor (α1A-AR) blocker. Silodosin exhibits high affinity for α1A-AR (Ki=0.036 nM), over 162-fold and 50-fold than for α1B-AR and α1D-AR with Ki values of 21 nM and 2.0 nM, respectively. Silodosin is an effective and well-tolerated agent, it can be used for the investigation of LUTS/BPH[1][3].
CAS Number
160970-54-7
Product Name Alternative
KAD 3213 (Standard) ; KMD 3213 (Standard)
UNSPSC
12352005
Target
Adrenergic Receptor; Bacterial; Reference Standards
Type
Reference Standards
Related Pathways
Anti-infection; GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/silodosin-standard.html
Smiles
O=C(N)C1=CC(C[C@@H](C)NCCOC2=CC=CC=C2OCC(F)(F)F)=CC3=C1N(CC3)CCCO
Molecular Formula
C25H32F3N3O4
Molecular Weight
495.53
References & Citations
[1]Maxime Rossi , Silodosin in the treatment of benign prostatic hyperplasia. Drug Des Devel Ther. 2010; 4: 291–297.|[2]Villa L, et al. Effects by silodosin on the partially obstructed rat ureter in vivo and on human and rat isolated ureters.Br J Pharmacol. 2013 May;169 (1) :230-8.|[3]Osman NI, et al.Silodosin : a new subtype selective alpha-1 antagonist for the treatment of lower urinary tract symptoms in patients with benign prostatic hyperplasia.Expert Opin Pharmacother. 2012 Oct;13 (14) :2085-96.|[4]Kawahara T, et al. Silodosin inhibits the growth of bladder cancer cells and enhances the cytotoxic activity of cisplatin via ELK1 inactivation.Am J Cancer Res. 2015 Sep 15;5 (10) :2959-68. eCollection 2015.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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