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α-Thujone

CAT: 804-HY-121618-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
10 mM - 1 mLSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
α-Thujone is a monoterpene isolated from Thuja occidentalis essential oil with potent anti-tumor activities. α-Thujone is a reversible modulator of the GABA type A receptor and the IC50 for α-Thujone is 21 μM in suppressing the GABA-induced currents. α-Thujone induces ROS accumulation-dependent cytotoxicity, also induces cell apoptosis and autophagy. α-Thujone has antinociceptive, insecticidal, and anthelmintic activity, and can cross the blood-brain barrier[1][2][3].
CAS Number
[546-80-5]
UNSPSC
12352211
Hazard Statement
H302
Target
Apoptosis; Autophagy; GABA Receptor; Parasite; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Autophagy; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/α-thujone.html
Purity
98.07
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C[C@]2(C(C)C)C[C@]2([H])[C@H]1C
Molecular Formula
C10H16O
Molecular Weight
152.24
Precautions
H302
References & Citations
[1]Agus HH, et al. Involvement of Pca1 in ROS-mediated apoptotic cell death induced by alpha-thujone in the fission yeast (Schizosaccharomyces pombe) . FEMS Yeast Res. 2020 Apr 29. pii: foaa022.|[2]Pudełek M, et al. Therapeutic potential of monoterpene α-thujone, the main compound of Thuja occidentalis L. essential oil, against malignant glioblastoma multiforme cells in vitro. Fitoterapia. 2019 Apr;134:172-181.|[3]Höld KM, et al. Alpha-thujone (the active component of absinthe) : gamma-aminobutyric acid type A receptor modulation and metabolic detoxification. Proc Natl Acad Sci U S A. 2000 Apr 11;97 (8) :3826-31.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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