α-Thujone (Standard)

• Description:

  α-Thujone (Standard) is the analytical standard of α-Thujone. This product is intended for research and analytical applications. α-Thujone is a monoterpene isolated from Thuja occidentalis essential oil with potent anti-tumor activities. α-Thujone is a reversible modulator of the GABA type A receptor and the IC50 for α-Thujone is 21 μM in suppressing the GABA-induced currents. α-Thujone induces ROS accumulation-dependent cytotoxicity, also induces cell apoptosis and autophagy. α-Thujone has antinociceptive, insecticidal, and anthelmintic activity, and easily penetrates the blood-brain barrier[1][2][3].

• UNSPSC:

  12352100

• Target:

  Apoptosis; Autophagy; GABA Receptor; Parasite; Reactive Oxygen Species (ROS) ; Reference Standards

• Related Pathways:

  Anti-infection; Apoptosis; Autophagy; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others

• Field of Research:

  Infection; Neurological Disease

• Smiles:

  O=C1C[C@]2(C(C)C)C[C@]2([H])[C@H]1C

• Molecular Formula:

  C10H16O

• Molecular Weight:

  152.24

• References & Citations:

  [1]Agus HH, et al. Involvement of Pca1 in ROS-mediated apoptotic cell death induced by alpha-thujone in the fission yeast (Schizosaccharomyces pombe) . FEMS Yeast Res. 2020 Apr 29. pii: foaa022.|[2]Pudełek M, et al. Therapeutic potential of monoterpene α-thujone, the main compound of Thuja occidentalis L. essential oil, against malignant glioblastoma multiforme cells in vitro. Fitoterapia. 2019 Apr;134:172-181.|[3]Höld KM, et al. Alpha-thujone (the active component of absinthe) : gamma-aminobutyric acid type A receptor modulation and metabolic detoxification. Proc Natl Acad Sci U S A. 2000 Apr 11;97 (8) :3826-31.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [546-80-5]