Mps1-IN-3 (hydrochloride)

Mps1-IN-3 (hydrochloride)

• CAS Number: 2989453-29-2
• UNSPSC Description: Mps1-IN-3 hydrochloride is a potent and selective Mps1 inhibitor with an IC50 value of 50 nM. Mps1-IN-3 hydrochloride can inhibit the proliferation of glioblastoma cells, and effectively sensitizes glioblastomas to Vincristine in orthotopic glioblastoma xenograft model[1].
• Target Antigen: Mps1
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Cytoskeleton
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/mps1-in-3-hydrochloride.html
• Purity: 98.04
• Solubility: DMSO : ≥ 20 mg/mL
• Smiles: OC1CCN(C2=CC=C(NC3=NC(NC4=CC=CC=C4S(=O)(C(C)C)=O)=C5N=CNC5=N3)C(OC)=C2)CC1.[H]Cl
• Molecular Weight: 574.09
• References & Citations: [1]Tannous BA, et al. Effects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs. J Natl Cancer Inst. 2013 Sep 4;105(17):1322-31.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported