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Antibacterial agent 218

CAT: 0804-HY-163631Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163631Size:1 Each
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Description
Antibacterial agent 218 (compound d28) is an orally active sterol 24-C-Methyltransferase inhibitor with the IC50 of 0.273 μM. Antibacterial agent 218 shows antifungal activity against the C.albicans SC5314 with the IC50 of 0.25 μg/mL[1].
CAS Number
9007-83-4
UNSPSC
12352005
Target
Endogenous Metabolite; Fungal
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/antibacterial-agent-218.html
Smiles
CN1C(C)=C(C(N1C2=CC=CC=C2)=O)N3/C(SC=C3C4=CC5=C(C=C4)C=CC=C5)=N/C6=CC=CC=C6
Molecular Formula
C30H24N4OS
Molecular Weight
488.60
References & Citations
[1]Wang X, et al. Structure-Based Optimization of Novel Sterol 24-C-Methyltransferase Inhibitors for the Treatment of Candida albicans Infections. J Med Chem. 2024;67 (11) :9318-9341.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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