ABBV-744
CAT:
804-HY-112090-06
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
ABBV-744
- CAS Number: 2138861-99-9
- UNSPSC Description: ABBV-744 is a first-in-class, orally active and selective inhibitor of the BDII domain of BET family proteins with IC50 values ranging from 4 to 18 nM for BRD2, BRD3, BRD4 and BRDT. ABBV-744 is primarily metabolized by CYP3A4 with agent-like properties enable the investigation of its antitumor efficacy and tolerability[1].
- Target Antigen: Epigenetic Reader Domain; HIV
- Type: Reference compound
- Related Pathways: Anti-infection;Epigenetics
- Applications: Cancer-programmed cell death
- Field of Research: Cancer; Infection; Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/ABBV-744.html
- Purity: 99.97
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: CC(O)(C)C1=CC(C(C2=C3NC(C(NCC)=O)=C2)=CN(C)C3=O)=C(OC4=C(C)C=C(F)C=C4C)C=C1
- Molecular Weight: 491.55
- References & Citations: [1]Faivre EJ, et al. Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer. Nature. 2020;578(7794):306-310.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, stored under nitrogen)
- Clinical Information: Phase 1