Products for Research Use Only
RegisterLogin

MZ82

CAT: 0804-HY-168572Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-168572Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
MZ82, Ko 143 derivative, is a ATP-binding cassette subfamily G member 2 (ABCG2/BCRP) inhibitor with the IC50 of ~23 nM. MZ82 not only shows greatly improved metabolic stability over Ko 143 (HY-10010) in liver microsomes but also in mice, and is able to penetrate into the brain[1].
CAS Number
2944457-11-6
UNSPSC
12352005
Target
BCRP
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mz82.html
Smiles
O=C1N[C@@H](CC2=CC=CC=C2)C(N3[C@@H](CC(C)C)C4=C(C5=CC=C(OC)C=C5N4)C[C@H]31)=O
Molecular Formula
C26H29N3O3
Molecular Weight
431.53
References & Citations
[1]Yu Q, et al. Modulation of ABCG2 Transporter Activity by Ko143 Derivatives. ACS Chem Biol. 2024 Nov 15;19 (11) :2304-2313.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
T200975-01MZ82

Popular Products