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MZ82

CAT: 0931-T200975-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T200975-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
BCRP
Related Pathways
Membrane transporter/Ion channel
Bioactivity
MZ82, a derivative of Ko 143, is a potent inhibitor of ATP-binding cassette sub-family G member 2 (ABCG2/BCRP), with an IC50 of approximately 23 nM. Compared to Ko 143, MZ82 exhibits significantly enhanced metabolic stability in liver microsomes and shows marked improvement in mice, along with the ability to penetrate the brain.
Smiles
C(O)(=O)C=1N2N(CC(NC(/C(=N\OC)/C3=CSC(N)=N3)=O)C2=O)CC1C#N
Molecular Formula
C26H29N3O3
Molecular Weight
431.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-168572MZ82

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