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Resveratrol-d4

CAT: 0804-HY-16561S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16561S-01Size:1 mg
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Description
Resveratrol-d4 is the deuterium labeled Resveratrol. Resveratrol (trans-Resveratrol; SRT501), a natural polyphenolic phytoalexin that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol (SRT 501) has a wide spectrum of targets including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, DNA polymerase. Resveratrol also is a specific SIRT1 activator[1][2][3][4]. Resveratrol is a potent pregnane X receptor (PXR) inhibitor[5]. Resveratrol is an Nrf2 activator, ameliorates aging-related progressive renal injury in mice model[6]. Resveratrol increases production of NO in endothelial cells[7].
CAS Number
1089051-56-8
Product Name Alternative
Trans-Resveratrol-d4; SRT501-d4
UNSPSC
12352005
Hazard Statement
H225, H350
Target
Antibiotic; Apoptosis; Autophagy; Bacterial; Fungal; IKK; Isotope-Labeled Compounds; Keap1-Nrf2; Mitophagy; Sirtuin
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics; NF-κB; Others
Field of Research
Cancer; Infection; Inflammation/Immunology
Purity
99.9
Solubility
DMF : ≥ 100mg/mL|DMSO : ≥ 50mg/mL|Ethanol : ≥ 50mg/mL
Smiles
OC1=CC(/C=C/C2=C([2H])C([2H])=C(O)C([2H])=C2[2H])=CC(O)=C1
Molecular Formula
C14H8D4O3
Molecular Weight
232.27
Precautions
H225, H350
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Pirola L, et al. Resveratrol: one molecule, many targets. IUBMB Life. 2008 May;60 (5) :323-32.|[3]Lu R, et al. Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells. J Cell Physiol. 1999 Jun;179 (3) :297-304.|[4]Lee MH, et al. Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target. Cancer Res. 2009 Sep 15;69 (18) :7449-58.|[5]Du LL, et al. Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi. Age (Dordr) . 2014 Apr;36 (2) :613-23.|[6]Smutny T, et al. Resveratrol as an inhibitor of pregnane X receptor (PXR) : another lesson in PXR antagonism. J Pharmacol Sci. 2014;126 (2) :177-8.|[7]Eun Nim Kim, et al. Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury. Aging (Albany NY) . 2018 Jan; 10 (1) : 83–99.|[8]Huige Li, et al. Resveratrol and Vascular Function. Int J Mol Sci. 2019 Apr 30;20 (9) :2155.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Chemical Information

trans-Resveratrol-d4
CAS Number1089051-56-8
PubChem CID71684637
IUPAC Name5-[(E)-2-(2,3,5,6-tetradeuterio-4-hydroxyphenyl)ethenyl]benzene-1,3-diol
Molecular FormulaC14H12O3
Molecular Weight232.27
XLogP3.1
Topological Polar Surface Area60.7
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count17
Formal Charge0
Complexity246
SMILES
[2H]C1=C(C(=C(C(=C1/C=C/C2=CC(=CC(=C2)O)O)[2H])[2H])O)[2H]
InChI
InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+/i3D,4D,5D,6D
InChIKey
LUKBXSAWLPMMSZ-RRQWMZAJSA-N
Chemical Structure
2D Structure
2D structure of trans-Resveratrol-d4
CAS: 1089051-56-8
CID: 71684637
Formula: C14H12O3
MW: 232.27
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight232.27
XLogP33.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass232.103751224
Monoisotopic Mass232.103751224
Topological Polar Surface Area60.7 Ų
Heavy Atom Count17
Formal Charge0
Complexity246
Isotope Atom Count4
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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AR-R01400-01Resveratrol-d4 4'-Glucuronide
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