Polyoxin B

CAT: 0804-HY-103027Size: InquireDry Ice: NoHazardous: No
CAT#:0804-HY-103027Size:Inquire
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
[19396-06-6]
UNSPSC Description
Polyoxin B is a potent chitin synthase inhibitor (IC50=0.08 mM) and an effective antifungal agent[1].
Target Antigen
Fungal
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/polyoxin-b.html
Solubility
10 mM in DMSO
Smiles
O[C@H]1[C@H](N(C(N2)=O)C=C(CO)C2=O)O[C@H]([C@H](NC([C@@H](N)[C@@H]([C@H](COC(N)=O)O)O)=O)C(O)=O)[C@H]1O
Molecular Weight
507.41
References & Citations
[1]Mi-Young Yoon, et al. Potent in vivo antifungal activity against powdery mildews of pregnane glycosides from the roots of Cynanchum wilfordii. J Agric Food Chem. 2011 Nov 23;59(22):12210-6|[2]Qinggang Ji, et al. Synthesis and biological evaluation of novel phosphoramidate derivatives of coumarin as chitin synthase inhibitors and antifungal agents. Eur J Med Chem. 2016 Jan 27;108:166-176
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Clinical Information
No Development Reported

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