Polyoxin B

• UNSPSC Description:

  Polyoxin B is a potent chitin synthase inhibitor (IC50=0.08 mM) and an effective antifungal agent[1].

• Target Antigen:

  Fungal

• Type:

  Natural Products

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/polyoxin-b.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@H]1[C@H](N(C(N2)=O)C=C(CO)C2=O)O[C@H]([C@H](NC([C@@H](N)[C@@H]([C@H](COC(N)=O)O)O)=O)C(O)=O)[C@H]1O

• Molecular Weight:

  507.41

• References & Citations:

  [1]Mi-Young Yoon, et al. Potent in vivo antifungal activity against powdery mildews of pregnane glycosides from the roots of Cynanchum wilfordii. J Agric Food Chem. 2011 Nov 23;59(22):12210-6|[2]Qinggang Ji, et al. Synthesis and biological evaluation of novel phosphoramidate derivatives of coumarin as chitin synthase inhibitors and antifungal agents. Eur J Med Chem. 2016 Jan 27;108:166-176

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  19396-06-6