TP-238 (hydrochloride)
CAT:
804-HY-114205A-02
Size:
5 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
TP-238 (hydrochloride)
- CAS Number: 2415263-05-5
- UNSPSC Description: TP-238 hydrochloride is a potent and selective dual CECR2/BPTF probe with IC50 values of 30 nM and 350 nM, respectively. TP-238 hydrochloride also inhibits BRD9 with a pIC50 of 5.9 and is less active against other 338 kinases[1][2].
- Target Antigen: Epigenetic Reader Domain
- Type: Reference compound
- Related Pathways: Epigenetics
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/tp-238-hydrochloride.html
- Purity: 99.0
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: CN(C)CCCOC1=CC=C(C=C1)C2=CC(NCCCN3N=CC=C3)=NC(S(=O)(C)=O)=N2.[H]Cl
- Molecular Weight: 495.04
- References & Citations: [1]Michael A Clegg, et al. Advancements in the Development of non-BET Bromodomain Chemical Probes. ChemMedChem. 2019 Feb 19;14(4):362-385.|[2]Peter D Ycas, et al. New Inhibitors for the BPTF Bromodomain Enabled by Structural Biology and Biophysical Assay Development. Org Biomol Chem. 2020 Jun 26.
- Shipping Conditions: Blue Ice
- Storage Conditions: -20°C (Powder, stored under nitrogen)
- Clinical Information: No Development Reported