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CAD204520

CAT: 0804-HY-164466-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-164466-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CAD204520, a SERCA inhibitor (IC50 = 0.34 μM), targets mutated over wild type NOTCH1 proteins in T-cell acute lymphoblastic leukemia (T-ALL) and mantle cell lymphoma (MCL) . CAD204520 can be used for T-ALL and MCL research[1].
CAS Number
2682205-20-3
UNSPSC
12352005
Target
Calcium Channel; Notch
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cad204520.html
Purity
99.22
Smiles
CCCC(C(C=CC(OC(F)(F)F)=C1)=C1N2)=C2C3N(CCN4CCOCC4)CCCC3
Molecular Formula
C23H32F3N3O2
Molecular Weight
439.51
References & Citations
[1]Matteo Marchesini, et al. Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia. Cell Chem Biol. 2020 Jun 18;27 (6) :678-697.e13.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
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