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(+/-) -Adomeglivant

CAT: 0804-HY-19904ASize: 1 EachDry Ice: NoHazardous: No
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Description
(+/-) -Adomeglivant ((+/-) -LY2409021) is a potent and selective glucagon receptor antagonist with hypoglycemic activity. (+/-) -Adomeglivant is effective in lowering blood sugar levels in both healthy people and people with type 2 diabetes. (+/-) -Adomeglivant is well tolerated by glucagon signaling blockade in patients with type 2 diabetes and significantly reduces fasting and postprandial blood glucose with a concomitant reversible elevation of aminotransferases. Glucagon signaling inhibition by (+/-) -Adomeglivant is a promising potential inhibitory approach for patients with type 2 diabetes and warrants further evaluation of its benefits and risks in longer clinical trials[1].
CAS Number
872260-47-4
Product Name Alternative
(+/-) -LY2409021
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Smiles
O=C(CCNC(C1=CC=C(C(CCC(F)(F)F)OC2=CC(C)=C(C3=CC=C(C(C)(C)C)C=C3)C(C)=C2)C=C1)=O)O
Molecular Formula
C32H36F3NO4
Molecular Weight
555.63
References & Citations
[1]The glucagon receptor antagonist LY2409021 has no effect on postprandial glucose in type 2 diabetes
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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