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Nitroaspirin

CAT: 0804-HY-123823-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-123823-01Size:1 mg
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Description
Nitroaspirin (NCX 4016) is a nitric oxide (NO) donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin (NCX 4016) has antithrombotic and anti-platelet properties and acts as a direct and irreversible inhibitor of COX-1. Nitroaspirin (NCX 4016) causes significant induction of cell cycle arrest and apoptosis in Cisplatin-resistant human ovarian cancer cells via down-regulation of EGFR/PI3K/STAT3 signaling and modulation of Bcl-2 family proteins[1][2][3][4].
CAS Number
175033-36-0
Product Name Alternative
NCX 4016
UNSPSC
12352005
Target
Apoptosis; COX
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nitroaspirin.html
Concentration
10mM
Purity
98.57
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(OC1=CC=CC(CO[N+]([O-])=O)=C1)C2=CC=CC=C2OC(C)=O
Molecular Formula
C16H13NO7
Molecular Weight
331.28
References & Citations
[1]Bertuglia S, et al. Antioxidant activity of nitro derivative of aspirin against ischemia-reperfusion in hamster cheekpouch microcirculation. Am J Physiol Gastrointest Liver Physiol. 2004 Mar;286 (3) :G437-43.|[2]Corazzi T, et al. Direct and irreversible inhibition of cyclooxygenase-1 by nitroaspirin (NCX 4016) . J Pharmacol Exp Ther. 2005 Dec;315 (3) :1331-7.|[3]Selvendiran K, et al. NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts. Cell Cycle. 2008 Jan 1;7 (1) :81-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
COX-1

Alternative Products

CatalogName
T16328-01Nitroaspirin
A19145-5Nitroaspirin 5mg
A19145-200Nitroaspirin 200mg
A19145-100Nitroaspirin 100mg
A19145-25Nitroaspirin 25mg
A19145-10Nitroaspirin 10mg
A19145-50Nitroaspirin 50mg
A19145-1Nitroaspirin 1mg
A19145-10mM-DNitroaspirin 10mM * 1mL in DMSO

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