DOPE-mPEG, MW 2000
CAT:
804-HY-W440988-02
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
DOPE-mPEG, MW 2000
- UNSPSC Description: DOPE-mPEG, MW 2000 is a phospholipid polydisperse PEG (or DOPE liposome), can be used for preparation of targeted delivery of liposomal drug and giant unilamellar vesicles (GUVs). DOPE-mPEG, MW 2000 significantly reduces the pH-sensitivity of the liposome in a concentration dependent manner[1][2][3].
- Target Antigen: Liposome
- Type: Reference compound
- Related Pathways: Metabolic Enzyme/Protease
- Field of Research: Others
- Assay Protocol: https://www.medchemexpress.com/dope-mpeg-mw-2000.html
- Purity: 95.0
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: CCCCCCCC/C=C\CCCCCCCC(OC[C@@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COP(OCCNC(OCCOC)=O)(O)=O)=O.[n]
- Molecular Weight: 2000(Average)
- References & Citations: [1]Shin J, et al. Acid-labile mPEG-vinyl ether-1,2-dioleylglycerol lipids with tunable pH sensitivity: synthesis and structural effects on hydrolysis rates, DOPE liposome release performance, and pharmacokinetics. Mol Pharm. 2012 Nov 5;9(11):3266-76.|[2]Su WC, et al. Pulsatile Gating of Giant Vesicles Containing Macromolecular Crowding Agents Induced by Colligative Nonideality. J Am Chem Soc. 2018 Jan 17;140(2):691-699.|[3]Xu H, et al. Enhanced pH-Responsiveness, Cellular Trafficking, Cytotoxicity and Long-circulation of PEGylated Liposomes with Post-insertion Technique Using Gemcitabine as a Model Drug. Pharm Res. 2015 Jul;32(7):2428-38.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported