DOPE-mPEG, MW 2000

• UNSPSC Description:

  DOPE-mPEG, MW 2000 is a phospholipid polydisperse PEG (or DOPE liposome), can be used for preparation of targeted delivery of liposomal drug and giant unilamellar vesicles (GUVs). DOPE-mPEG, MW 2000 significantly reduces the pH-sensitivity of the liposome in a concentration dependent manner[1][2][3].

• Target Antigen:

  Liposome

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/dope-mpeg-mw-2000.html

• Purity:

  95.0

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CCCCCCCC/C=C\CCCCCCCC(OC[C@@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COP(OCCNC(OCCOC)=O)(O)=O)=O.[n]

• Molecular Weight:

  2000(Average)

• References & Citations:

  [1]Shin J, et al. Acid-labile mPEG-vinyl ether-1,2-dioleylglycerol lipids with tunable pH sensitivity: synthesis and structural effects on hydrolysis rates, DOPE liposome release performance, and pharmacokinetics. Mol Pharm. 2012 Nov 5;9(11):3266-76.|[2]Su WC, et al. Pulsatile Gating of Giant Vesicles Containing Macromolecular Crowding Agents Induced by Colligative Nonideality. J Am Chem Soc. 2018 Jan 17;140(2):691-699.|[3]Xu H, et al. Enhanced pH-Responsiveness, Cellular Trafficking, Cytotoxicity and Long-circulation of PEGylated Liposomes with Post-insertion Technique Using Gemcitabine as a Model Drug. Pharm Res. 2015 Jul;32(7):2428-38.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported