Urea-d4

• Description:

  Urea-d4 is the deuterium labeled Urea[1]. Urea is a powerful protein denaturant via both direct and indirect mechanisms[2]. A potent emollient and keratolytic agent[3]. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function[4]. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry.

• Product Name Alternative:

  Carbonyl diamide-d4

• UNSPSC:

  12352211

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  Endogenous Metabolite

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Others

• Purity:

  99.95

• Solubility:

  10 mM in DMSO|DMSO : 100mg/mL (ultrasonic) |H2O : 100mg/mL (ultrasonic)

• Smiles:

  [2H]N([2H])C(N([2H])[2H])=O

• Molecular Formula:

  CD4N2O

• Molecular Weight:

  64.08

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Bennion BJ, et al. The molecular basis for the chemical denaturation of proteins by urea. Proc Natl Acad Sci U S A. 2003 Apr 29;100 (9) :5142-7.|[3]Pan M, et al. Urea: a comprehensive review of the clinical literature. Dermatol Online J. 2013 Nov 1519 (11) :20392.Wang H, et al. Urea. Subcell Biochem. 201473:7-29.|[4]Wang H, et al. Urea. Subcell Biochem. 201473:7-29.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  [1433-11-0]