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DFHO

CAT: 0804-HY-136277-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-136277-01Size:1 mg
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Description
DFHO is a fluorogenic ligand of Corn fluorogenic aptamer. The RNA aptamer, Corn binds DFHO with a Kd value of 70 nM and converts it to a fluorescent form, enabling RNA imaging in cells[1][2].
CAS Number
1420815-34-4
UNSPSC
12171500
Target
Fluorescent Dye
Type
Dye Reagents
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/dfho.html
Purity
99.83
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(N1C)/C(N=C1/C=N/O)=C\C(C=C2F)=CC(F)=C2O
Molecular Formula
C12H9F2N3O3
Molecular Weight
281.21
References & Citations
[1]Wenjiao Song, et al. Imaging RNA polymerase III transcription using a photostable RNA-fluorophore complex. Nat Chem Biol. 2017 Nov;13 (11) :1187-1194.|[2]Hyaeyeong Kim, et al. A Fluorogenic RNA-Based Sensor Activated by Metabolite-Induced RNA Dimerization. Cell Chem Biol. 2019 Dec 19;26 (12) :1725-1731.e6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported

Chemical Information

(5E)-5-[(3,5-difluoro-4-hydroxyphenyl)methylidene]-3-methyl-2-(nitrosomethylidene)imidazolidin-4-one
CAS Number1420815-34-4
PubChem CID154723879
IUPAC Name(5E)-5-[(3,5-difluoro-4-hydroxyphenyl)methylidene]-3-methyl-2-(nitrosomethylidene)imidazolidin-4-one
Molecular FormulaC12H9F2N3O3
Molecular Weight281.21
XLogP1.2
Topological Polar Surface Area82
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count1
Heavy Atom Count20
Formal Charge0
Complexity469
SMILES
CN1C(=CN=O)N/C(=C/C2=CC(=C(C(=C2)F)O)F)/C1=O
InChI
InChI=1S/C12H9F2N3O3/c1-17-10(5-15-20)16-9(12(17)19)4-6-2-7(13)11(18)8(14)3-6/h2-5,16,18H,1H3/b9-4+,10-5?
InChIKey
GXOMNFVJDRZPKL-KWBNEJDUSA-N
Chemical Structure
2D Structure
2D structure of (5E)-5-[(3,5-difluoro-4-hydroxyphenyl)methylidene]-3-methyl-2-(nitrosomethylidene)imidazolidin-4-one
CAS: 1420815-34-4
CID: 154723879
Formula: C12H9F2N3O3
MW: 281.21
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight281.21
XLogP31.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count1
Exact Mass281.06119748
Monoisotopic Mass281.06119748
Topological Polar Surface Area82 Ų
Heavy Atom Count20
Formal Charge0
Complexity469
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count1
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
C8223-10DFHO

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