Poly (I:C):Kanamycin (1:1) (sodium)

Poly (I:C):Kanamycin (1:1) (sodium)

• UNSPSC Description: Poly (I:C):Kanamycin (1:1) sodium is an isometric complex of Poly (I:C) (HY-135748) and Kanamycin (HY-16566). Poly(I:C) sodium, a synthetic analog of double-stranded RNA, is a TLR3 and retinoic acid-inducible gene I receptor (RIG-I and b>MDA5) agonist. Poly(I:C) sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses and induce apoptosis in cancer cells[1][2]. Kanamycin is an orally active antibacterial agent (Gram-negative/positive bacteria) that inhibits translocation and causes miscoding by binding to the 70S ribosomal subunit. Kanamycin shows good inhibitory activity against Mycobacterium tuberculosis (susceptible and drug-resistant) and Klebsiella pneumoniae, and can be used in the research of tuberculosis and pneumonia[3][4][5][6].
• Target Antigen: Apoptosis; Toll-like Receptor (TLR)
• Type: Reference compound
• Related Pathways: Apoptosis;Immunology/Inflammation
• Field of Research: Cancer; Infection
• Assay Protocol: https://www.medchemexpress.com/poly-i-c-kanamycin-1-1-sodium.html
• Smiles: [Poly (I:C):Kanamycin (1:1) (sodium)]
• References & Citations: [1]Robert Field, et al. Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNalpha/beta and IL-1beta responses in the diseased brain and exacerbates chronic neurodegeneration. Brain Behav Immun. 2010 Aug;24(6):996-1007. |[2]Besch R, et al. Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells. J Clin Invest. 2009 Aug;119(8):2399-411. |[3]Cheng YS, et al. Anticancer function of polyinosinic-polycytidylic acid. Cancer Biol Ther. 2010 Dec 15;10(12):1219-23.
• Shipping Conditions: Blue Ice