Kanamycin

• UNSPSC Description:

  Kanamycin (Kanamycin A) is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia[1][2][3][4].

• Target Antigen:

  Antibiotic; Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/kanamycin.html

• Solubility:

  H2O : 70 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O[C@H]1[C@](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@@]3([H])O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)([H])O[C@H](CN)[C@@H](O)[C@@H]1O

• Molecular Weight:

  484.50

• References & Citations:

  [1]YANAGISAWA K, et al. Studies on kanamycin, a new antibiotic against tubercle bacilli. I. Effect on virulent tubercle bacilli in vitro and in mice. J Antibiot (Tokyo). 1957 Nov;10(6):233-5. |[2]Nishi T, et al. Experimental respiratory tract infection with Klebsiella pneumoniae DT-S in mice: chemotherapy with kanamycin. Antimicrob Agents Chemother. 1980 Mar;17(3):494-505.|[3]Misumi M, et al. Interaction of kanamycin and related antibiotics with the large subunit of ribosomes and the inhibition of translocation. Biochem Biophys Res Commun. 1978 Sep 29;84(2):358-65. |[4]Misumi M, et al. Mechanism of inhibition of translocation by kanamycin and viomycin: a comparative study with fusidic acid. Biochem Biophys Res Commun. 1980 Jan 29;92(2):647-54.Adv Sci (Weinh). 2024 Jun 21.|Food Chem. 2022 Sep 26;403:134399.|Int J Med Microbiol. 2023 Mar 28;313(2):151578.|J Periodontol. 2024 Jul 4.|Vet Res Commun. 2024 Sep 26.|ACS Chem Biol. 2021 Dec 15.|ACS Infect Dis. 2024 Apr 12;10(4):1327-1338.|Cell Death Dis. 2021 May 18;12(6):509.|Int J Hydrogen Energy. 2018, 43(30), 13821-13828.|Microb Biotechnol. 2021 Mar 15.|Nucleic Acids Res. 2022 Dec 12;gkac1141.|Sci Adv. 2023 Feb 17;9(7):eade4770.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  Launched

• CAS Number:

  59-01-8