Mavatrep

Mavatrep

• CAS Number: 956274-94-5
• UNSPSC Description: Mavatrep (JNJ-39439335) is an orally active, selective and potent TRPV1 antagonist with high affinity for hTRPV1 channels (Ki=6.5 nM). Mavatrep antagonizes capsaicin-induced Ca2+ influx with an IC50 value of 4.6 nM. Mavatrep can be used in some studies of neuropathic pain[1].
• Target Antigen: TRP Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/Mavatrep.html
• Solubility: DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: OC(C)(C)C1=CC=CC=C1C2=CC=C3N=C(/C=C/C4=CC=C(C(F)(F)F)C=C4)NC3=C2
• Molecular Weight: 422.44
• References & Citations: [1]Parsons W H, et al. Benzo [d] imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1 H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep). Journal of medicinal chemistry, 2015, 58(9): 3859-3874.
• Shipping Conditions: Room Temperature
• Clinical Information: Phase 1