Mavatrep

CAT: 0804-HY-16935-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-16935-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Mavatrep (JNJ-39439335) is an orally active, selective and potent TRPV1 antagonist with high affinity for hTRPV1 channels (Ki=6.5 nM) . Mavatrep antagonizes capsaicin-induced Ca2+ influx with an IC50 value of 4.6 nM. Mavatrep can be used in some studies of neuropathic pain[1].

CAS Number

956274-94-5

Product Name Alternative

JNJ-39439335

UNSPSC

12352005

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Mavatrep.html

Purity

99.67

Solubility

DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC(C)(C)C1=CC=CC=C1C2=CC=C3N=C(/C=C/C4=CC=C(C(F)(F)F)C=C4)NC3=C2

Molecular Formula

C25H21F3N2O

Molecular Weight

422.44

References & Citations

[1]Parsons W H, et al. Benzo [d] imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2- (2-{2-[2- (4-Trifluoromethyl-phenyl) -vinyl]-1 H-benzimidazol-5-yl}-phenyl) -propan-2-ol (Mavatrep) . Journal of medicinal chemistry, 2015, 58 (9) : 3859-3874.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

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B5930-5.1	mavatrep
A15778-500	Mavatrep 500mg
A15778-25	Mavatrep 25mg
A15778-100	Mavatrep 100mg
A15778-50	Mavatrep 50mg
A15778-10	Mavatrep 10mg
A15778-5	Mavatrep 5mg
A15778-2	Mavatrep 2mg
A15778-1	Mavatrep 1mg
MBS130739-01	Mavatrep, JNJ-39439335

Mavatrep

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