SC209

• Description:

  SC209 (3-Aminophenyl Hemiasterlin) is a 3-aminophenyl hemiasterlin derivative that serves as a cytotoxin for ADCs, targeting tubulin. SC209 has reduced potential for drug efflux via P-glycoprotein 1 drug pump compared with other tubulin-targeting payloads. SC209 exhibits antitumor activity and can be used in the synthesis of ADC molecules[1][2].

• Product Name Alternative:

  3-Aminophenyl Hemiasterlin

• UNSPSC:

  12352203

• Target:

  ADC Payload; Microtubule/Tubulin; P-glycoprotein

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton; Membrane Transporter/Ion Channel

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/sc209.html

• Purity:

  99.52

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  OC(/C(C)=C/[C@H](C(C)C)N(C)C([C@H](C(C)(C)C)NC([C@@H](NC)C(C)(C1=CC(N)=CC=C1)C)=O)=O)=O

• Molecular Formula:

  C27H44N4O4

• Molecular Weight:

  488.66

• References & Citations:

  [1]Alice Yam, et al. Bispecific antibody-drug conjugates targeting egfr and muc1 and uses thereof. Patent. WO2021247798. 2021-12-09.|[2]De Almeida V, et al. Preclinical activity and safety of STRO-002, a novel ADC targeting folate receptor alpha for ovarian cancer. Gynecologic Oncology, 2018, 149: 50.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• CAS Number:

  [1977557-86-0]