SC209

CAT: 0804-HY-144880-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-144880-01Size:1 mg
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Description
SC209 (3-Aminophenyl Hemiasterlin) is a 3-aminophenyl hemiasterlin derivative that serves as a cytotoxin for ADCs, targeting tubulin. SC209 has reduced potential for drug efflux via P-glycoprotein 1 drug pump compared with other tubulin-targeting payloads. SC209 exhibits antitumor activity and can be used in the synthesis of ADC molecules[1][2].
CAS Number
[1977557-86-0]
Product Name Alternative
3-Aminophenyl Hemiasterlin
UNSPSC
12352203
Target
ADC Payload; Microtubule/Tubulin; P-glycoprotein
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton; Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sc209.html
Purity
99.52
Solubility
DMSO : ≥ 100 mg/mL
Smiles
OC(/C(C)=C/[C@H](C(C)C)N(C)C([C@H](C(C)(C)C)NC([C@@H](NC)C(C)(C1=CC(N)=CC=C1)C)=O)=O)=O
Molecular Formula
C27H44N4O4
Molecular Weight
488.66
References & Citations
[1]Alice Yam, et al. Bispecific antibody-drug conjugates targeting egfr and muc1 and uses thereof. Patent. WO2021247798. 2021-12-09.|[2]De Almeida V, et al. Preclinical activity and safety of STRO-002, a novel ADC targeting folate receptor alpha for ovarian cancer. Gynecologic Oncology, 2018, 149: 50.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported

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