SC239

CAT: 0804-HY-148194-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-148194-01Size:1 mg
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Description
SC239 is a cleavable 2-aminophenyl hemiasterlin agent-linker. SC239 can be as the agent-linker for ADC[1]. SC239 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
CAS Number
[1977557-97-3]
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sc239.html
Purity
99.97
Solubility
DMSO : 75 mg/mL (ultrasonic)
Smiles
O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC(C=C4)=CC=C4COC(NC5=CC(C(C)(C)[C@H](NC)C(N[C@@H](C(C)(C)C)C(N(C)[C@@H](C(C)C)/C=C(C)/C(O)=O)=O)=O)=CC=C5)=O)=O)=O)=O
Molecular Formula
C65H84N10O11
Molecular Weight
1181.42
References & Citations
[1]Xiaofan Li, et al. Abstract 1782: Discovery and activity of STRO-002, a novel ADC targeting folate receptor alpha for ovarian and endometrial cancer. Cancer Res (2018) 78 (13_Supplement) : 1782.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
ADC Related
Clinical Information
No Development Reported

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