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GSK2324

CAT: 0804-HY-113567-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113567-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK2324 (Compd 1c) is a FXR agonist for diabetes study, with an EC50 of 120 nM. GSK2324 exhibits t1/2 values of 84 min (mouse), 170 min (rat), 110 min (beagle) and 120 min (cyno), respectively[1].
CAS Number
1020567-30-9
Product Name Alternative
MK5435
UNSPSC
12352005
Target
FXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/gsk2324.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NC2=CC=C(C3=CC=C(OCC4=C(C(C)C)ON=C4C5=C(Cl)C=CC=C5Cl)C=C3)C=C2C=C1)O
Molecular Formula
C29H22Cl2N2O4
Molecular Weight
533.40
References & Citations
[1]Jonathan Y Bass, et al. Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene. Bioorg Med Chem Lett. 2011 Feb 15;21 (4) :1206-13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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