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LML134

CAT: 0804-HY-128656-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-128656-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LML134 (compound 18b) is an orally active and high selective Histamine 3 receptor (H3R) inverse agonist with Kis of 0.3 nM and 12 nM for hH3R cAMP and hH3R bdg. LML134 penetrates the brain rapidly, leading to high H3R occupancy, and disengages its target with a fast kinetic profile. LML134 has the potential for excessive sleep disorders[1].
CAS Number
1542135-76-1
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/lml134.html
Purity
99.43
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
O=C(OC1CCN(C2=NN(C)C(C=C2)=O)CC1)N3CCN(C4CCC4)CC3
Molecular Formula
C19H29N5O3
Molecular Weight
375.47
References & Citations
[1]Troxler T, et al. The Discovery of LML134, a Histamine H3 Receptor Inverse Agonist for the Clinical Treatment of Excessive Sleep Disorders. ChemMedChem. 2019 Jul 3;14 (13) :1238-1247.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
H3 Receptor

Alternative Products

CatalogName
BA5431-5LML134

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