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LML134

CAT: 0013-GTR19165724-03Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19165724-03Size:1 ml x 10 mM (in DMSO)
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Description
LML134 (LML-134) is a potent and selective inverse agonist of the human Histamine H3 Receptor (H3R), demonstrating high affinity with Kis of 0.3 nM in cAMP assays and 12 nM in binding assays. This small molecule is a valuable research tool for investigating H3R function in neurological disorders, supporting both in vitro mechanistic studies and in vivo preclinical research.
CAS Number
1542135-76-1
Product Name Alternative
H3 receptor, Histamine Receptor, HistamineReceptor, Inhibitor, LML 134, LML134, LML-134, inhibit
Field of Research
Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery
Purity
99.36% (May vary between batches)
Solubility
DMSO:7.5 mg/mL (19.97 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.66 mM)
Smiles
Cn1nc (ccc1=O) N1CCC (CC1) OC (=O) N1CCN (CC1) C1CCC1
Molecular Formula
C19H29N5O3
Molecular Weight
375.47
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Lml-134
CAS Number1542135-76-1
PubChem CID72948400
IUPAC Name[1-(1-methyl-6-oxopyridazin-3-yl)piperidin-4-yl] 4-cyclobutylpiperazine-1-carboxylate
Molecular FormulaC19H29N5O3
Molecular Weight375.5
XLogP0.6
Topological Polar Surface Area68.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count27
Formal Charge0
Complexity629
SMILES
CN1C(=O)C=CC(=N1)N2CCC(CC2)OC(=O)N3CCN(CC3)C4CCC4
InChI
InChI=1S/C19H29N5O3/c1-21-18(25)6-5-17(20-21)23-9-7-16(8-10-23)27-19(26)24-13-11-22(12-14-24)15-3-2-4-15/h5-6,15-16H,2-4,7-14H2,1H3
InChIKey
BVUJMFFRMZRNAT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Lml-134
CAS: 1542135-76-1
CID: 72948400
Formula: C19H29N5O3
MW: 375.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight375.5
XLogP30.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass375.22703980
Monoisotopic Mass375.22703980
Topological Polar Surface Area68.7 Ų
Heavy Atom Count27
Formal Charge0
Complexity629
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA5431-5LML134

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