L-Quebrachitol

• Description:

  L-Quebrachitol is a methoxy analog of inositol that can be isolated from plants. L-Quebrachitol has free-radical scavenging, gastroprotection, anti-platelet aggregation and anti-diabetic activity. L-Quebrachitol promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway[1][2][3].

• UNSPSC:

  12352211

• Hazard Statement:

  H315, H319, H335

• Target:

  P38 MAPK; Wnt; β-catenin

• Type:

  Natural Products

• Related Pathways:

  MAPK/ERK Pathway; Stem Cell/Wnt

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/l-quebrachitol.html

• Concentration:

  10mM

• Purity:

  98.0

• Solubility:

  DMSO : 125 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

• Smiles:

  CO[C@H]1[C@@H] ([C@H] ([C@H] (O) [C@H] (O) [C@H]1O) O) O

• Molecular Formula:

  C7H14O6

• Molecular Weight:

  194.18

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Yodthong T, et al. l-Quebrachitol Promotes the Proliferation, Differentiation, and Mineralization of MC3T3-E1 Cells: Involvement of the BMP-2/Runx2/MAPK/Wnt/β-Catenin Signaling Pathway. Molecules. 2018 Nov 26;23 (12) .|[2]Li Y, et al. L-quebrachitol extracted from industrial rubber serum: a study on its antioxidant activities and bone mineral density enhancing functions[J]. Industrial Crops and Products, 2023, 201: 116943.|[3]Mu Y, et al. Sea buckthorn leaf l-quebrachitol extract for improved glucose and lipid metabolism in insulin resistant HepG2 Cells[J]. Bioresources, 2022, 17 (1) : 527.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  642-38-6