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KIF18A-IN-1

CAT: 0804-HY-145034-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-145034-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KIF18A-IN-1 is an inhibitor of the mitotic kinesin KIF18A with anti-tumor activity. KIF18A targeted inhibitors may activate mitotic checkpoints and selectively kill chromosomally unstable cancer cells[1][2].
CAS Number
2600559-12-2
UNSPSC
12352005
Target
Kinesin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kif18a-in-1.html
Purity
98.39
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(S(=O)(NC(C)(C)C)=O)C=C1N2CCC3(CC3)CC2)NC4=CC=CC(S(=O)(NC(C)(C)C)=O)=C4
Molecular Formula
C28H40N4O5S2
Molecular Weight
576.77
References & Citations
[1]Pharmaceutical compositions comprising kinesin-like protein KIF18A inhibitors for the treatment of cancer. World Intellectual Property Organization, WO2023212714 A1 2023-11-02.|[2]Payton M, et al. Small-molecule inhibition of kinesin KIF18A reveals a mitotic vulnerability enriched in chromosomally unstable cancers. Nat Cancer. 2024 Jan;5 (1) :66-84.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
BA4237-5KIF18A-IN-1
MBS6002075-01KIF18A, CT (KIF18A, Kinesin-like protein KIF18A, Marrow stromal KIF18A)
524734-01KIF18A
037435-PEKIF18A, CT (KIF18A, Kinesin-like protein KIF18A, Marrow stromal KIF18A) (PE)
MBS6313228-01KIF18A, CT (KIF18A, Kinesin-like protein KIF18A, Marrow stromal KIF18A) (Biotin)
MBS6313229-01KIF18A, CT (KIF18A, Kinesin-like protein KIF18A, Marrow stromal KIF18A) (FITC)
MBS6313227-01KIF18A, CT (KIF18A, Kinesin-like protein KIF18A, Marrow stromal KIF18A) (APC)
MBS6313226-01KIF18A, CT (KIF18A, Kinesin-like protein KIF18A, Marrow stromal KIF18A) (AP)
037435-BiotinKIF18A, CT (KIF18A, Kinesin-like protein KIF18A, Marrow stromal KIF18A) (Biotin) discontinued
037435-APKIF18A, CT (KIF18A, Kinesin-like protein KIF18A, Marrow stromal KIF18A) (AP) discontinued

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