KIF18A-IN-3

KIF18A-IN-3

• CAS Number: 2600577-49-7
• UNSPSC Description: KIF18A-IN-3 is a potent KIF18A inhibitor (IC50=61 nM). KIF18A-IN-3 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-3 can be used for researching cancer[1].
• Target Antigen: Kinesin; Microtubule/Tubulin
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Cytoskeleton
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/kif18a-in-3.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(C1=CC=C(NS(C2(C)CC2)(=O)=O)C=C1N3CCC4(CC4)CC3)NC5=CC=CC(S(NC(C)(C)C)(=O)=O)=C5
• Molecular Weight: 574.76
• References & Citations: [1]Tamayo NA, et al. Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe. J Med Chem. 2022;65(6):4972-4990.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported