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GA32

CAT: 0804-HY-163340-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-163340-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GA32 (compound 58r) is potent androgen receptor (AR) /glucocorticoid receptor (GR) dual inhibitor with IC50 values of 0.13 μM and 0.83 μM for AR and GR, respectively. GA32 inhibits the proliferation of Enzalutamide resistance castration-resistant prostate cancer both in vitro and in vivo[1].
CAS Number
1386811-71-7
UNSPSC
12352005
Target
Androgen Receptor; Glucocorticoid Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ga32.html
Purity
99.67
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC1=CC=C(NC(C2=CC=CC(S(=O)(N3C4=C(CCC3)C=CC=C4)=O)=C2)=O)C=C1
Molecular Formula
C23H19N3O3S
Molecular Weight
417.48
References & Citations
[1]Li C, et al. Design and Synthesis of Dual-Target Inhibitors Targeting Androgen Receptors and Glucocorticoid Receptors to Overcome Antiandrogen Resistance in Castration-Resistant Prostate Cancer. J Med Chem. 2024 Feb 22.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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