L-655708

CAT: 0804-HY-14426-01Size: 5 mgDry Ice: NoHazardous: No

CAT#:0804-HY-14426-01Size:5 mg

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Description

L-655708 is a potent α5 subunit-selective GABAA receptor inverse agonist (Ki=0.45 nM) .

CAS Number

[130477-52-0]

UNSPSC

12352005

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/L-655708.html

Concentration

10mM

Purity

99.88

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

COC1=CC=C(C2=C1)N3C=NC(C(OCC)=O)=C3[C@@]4([H])N(CCC4)C2=O

Molecular Formula

C18H19N3O4

Molecular Weight

341.36

References & Citations

[1]Saab BJ, et al. Short-term memory impairment after isoflurane in mice is prevented by the α5 γ-aminobutyric acid type A receptorinverse agonist L-655708. Anesthesiology. 2010 Nov;113 (5) :1061-1071.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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MBS3845612-01	L-655708
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A21181-5	L-655708 5mg
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M41812-01	A-L-A-L
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L-655708

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