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Osavampator

CAT: 0804-HY-115864-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-115864-01Size:5 mg
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Description
Osavampator (TAK-653) is a AMPA receptor positive allosteric modulator. Osavampator selectively binds to AMPA-R in a glutamate-dependent manner and induces Ca2+ influx in hGluA1i CHO cells (EC50 = 3.3 μM) . Osavampator improves learning and memory in many models. Osavampator is can be used for the research of depressive disorders[1][2].
CAS Number
1358751-06-0
Product Name Alternative
TAK-653; NBI-1065845
UNSPSC
12352005
Target
IGluR; Lipoxygenase
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/osavampator.html
Purity
99.74
Solubility
DMSO : ≥ 12.5 mg/mL
Smiles
O=S1(N=C2C(C3=CC=C(C=C3)OC4CCCCC4)=NC(C)=CN2CC1)=O
Molecular Formula
C19H23N3O3S
Molecular Weight
373.47
References & Citations
[1]Hara H, et al. TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats. Pharmacol Biochem Behav. 2021 Dec;211:173289. |[2]Hara H, et al. TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats [J]. Pharmacology Biochemistry and Behavior, 2021, 211: 173289.|[3]Suzuki A, et al. Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement [J]. Scientific Reports, 2021, 11 (1) : 14532.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
5-LOX; AMPA Receptor

Alternative Products

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C03620-01Osavampator
A24252-100Osavampator (TAK-653, NBI-1065845) 100mg
A24252-50Osavampator (TAK-653, NBI-1065845) 50mg
A24252-10Osavampator (TAK-653, NBI-1065845) 10mg
A24252-5Osavampator (TAK-653, NBI-1065845) 5mg

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