VH032-PEG5-C6-Cl

VH032-PEG5-C6-Cl

• CAS Number: 1799506-06-1
• UNSPSC Description: VH032-PEG5-C6-Cl (HaloPROTAC 2) is a conjugate of ligands for E3 and 21-atom-length linker. The connector of linker is Halogen group. VH032-PEG5-C6-Cl incorporates the VH032 based VHL ligand and 5-unit PEG linker. VH032-PEG5-C6-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].
• Target Antigen: E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/HaloPROTAC_1.html
• Purity: 99.93
• Solubility: DMSO : 270 mg/mL (ultrasonic)|Ethanol : 100 mg/mL (ultrasonic)
• Smiles: O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(COCCOCCOCCOCCOCCCCCCCl)=O)=O)C[C@H](O)C3
• Molecular Weight: 783.41
• References & Citations: [1]Buckley DL, et al. HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins. ACS Chem Biol. 2015 Aug 21;10(8):1831-7.
• Shipping Conditions: Dry Ice
• Storage Conditions: -80°C, protect from light, stored under nitrogen
• Clinical Information: No Development Reported