HIF-2α-IN-4

HIF-2α-IN-4

• CAS Number: 882268-69-1
• UNSPSC Description: HIF-2α-IN-4 is a potent inhibitor of hypoxia inducible factor-2α (HIF-2α) translation, with an IC50 of 5 μM. HIF-2α-IN-4 decreases both constitutive and hypoxia-induced HIF-2α protein expression. HIF-2α-IN-4 links its 5'UTR iron-responsive element to oxygen sensing[1].
• Target Antigen: HIF/HIF Prolyl-Hydroxylase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hif-2α-in-4.html
• Smiles: O=C(C1=C(N/N=C(C#N)/S(=O)(C)=O)C=CS1)OC
• Molecular Weight: 287.32
• References & Citations: [1]Zimmer M, et al. Small-molecule inhibitors of HIF-2α translation link its 5'UTR iron-responsive element to oxygen sensing. Mol Cell. 2008;32(6):838-848.
• Shipping Conditions: Room Temperature