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5-O-Methylembelin

CAT: 0804-HY-W510159-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W510159-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9, inducible degrader of the low-density lipoprotein receptor (IDLR), and sterol regulatory element binding protein 2 (SREBP2) mRNA expression[1].
CAS Number
56005-10-8
UNSPSC
12352211
Hazard Statement
H302+H312+H332, H315, H319
Target
PCSK9
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/5-o-methylembelin.html
Purity
99.43
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCCCCCCCCCC1=C(C(C=C(C1=O)OC)=O)O
Molecular Formula
C18H28O4
Molecular Weight
308.41
Precautions
H302+H312+H332, H315, H319
References & Citations
[1]Pisey Pel, et al. Isocoumarins and Benzoquinones with Their Proprotein Convertase Subtilisin/Kexin Type 9 Expression Inhibitory Activities from Dried Roots of Lysimachia vulgaris. ACS Omega. 2022 Dec 8;7 (50) :47296-47305.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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